Previous Faculty Publications

Below you will find a selection of research articles published by members of the IMPRS-TP faculty prior to 2022.

Cover of Neuron, 2014 Volume 83, Issue 2: Maintaining proper level of centrally expressed microRNA molecules is essential for intact emotional response to challenge. The image depicts an “umbrella of microRNAs” protecting the individual from “rain” of life stressors and challenges associated with bad feelings and psychopathologies such as depression and anxiety. Issler et al. (pages 344–360) describe the microRNA fingerprint of serotonergic neurons and demonstrate the important of microRNA-135 for proper serotonergic activity, behavioral stress resiliency, and antidepressant efficacy. Image illustrated by Genia Brodsky.

Engel M, ..., Wotjak CT, Schmidt MV, Deussing JM, Binder EB, Chen A. The Role of m6A/m-RNA Methylation in Stress Response Regulation. Neuron Volume 99, Issue 2, p389–403.e9, 25 July 2018

Ezra-Nevo G, ..., Deussing JM, ... and Chen A. Cerebellar Learning Properties Are Modulated by the CRF Receptor. J of Neurosc. 25 July 2018, 38 (30) 6751-6765

Ramot, A., ... & Chen, A. Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nat Neurosci. 2017 Jan 30. Epub ahead of print

Schroeder M, ...., and Chen A. A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype. Cell Metabolism (2017), http://dx.doi.org/10.1016/j.cmet.2017.05.001

Henckens MJAG, …, Deussing JM, …, and Chen A. CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery. Molecular Psychiatry (2016) 00, 1–10, Open Acess

Volk N, Pape JC, ... Binder EB & Chen A. Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. Cell Reports 17, 1882–1891 November 8, 2016

Kuperman Y, Weiss M, Dine J, ..., Deussing J, Eder M and Chen A. CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. Cell Metabolism June 14, 2016: 23, 1–15; OPEN ACCESS 

Elliott E, Manashirov S, Zwang R, Gil S, Tsoory M and Chen A. Dnmt3a in the medial prefrontal cortex regulates anxiety-like behavior in adult mice. J Neurosci. 2016 Jan 20;36(3):730-40

Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A. MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron. 2014 Jul 16;83(2):344-60

Shemesh Y, Sztainberg Y, Forkosh O, Shlapobersky T, Chen A*, Schneidman E*. High-order social interactions in groups of mice. eLife 2013 Sep 3; 2:e00759.

Lebow L, Neufeld-Cohen A, Kuperman Y, Gil S and Chen A. Susceptibility to PTSD is mediated by CRF receptor type 2 levels in the bed nucleus of the stria terminalis. J Neurosci. 2012 May 16; 32:6906-6916.

Shemesh Y, ...Deussing JM, ...& Chen A. Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. Nature Neuroscience, 2016, doi:10.1038/nn.4346

N Dedic , …, CT Wotjak ,  …, A Chen,  …, MV Schmidt , EB Binder and JM Deussing. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. Molecular Psychiatry (2018) 23, 533–543 OPEN ACCESS 

Dedic N, ..., Wotjak CT, ..., Chen A, Schmidt MV, ..., Deussing JM; Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety; Nature Neuroscience (2018), 21(6):803-807

Metzger MW, ..., Schmidt MV, ..., Chen A, ...& Deussing JM: Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality. J Neurosci 2017, 37 (48) 11688-11700 Open Access Article

Dedic N, … Wotjak CT, … Chen A, … Schmidt MV, Binder EB and Deussing JM. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.
Mol Psychiatry. 2017 Jul 11

Kumar D, , Dedic N, Flachskamm C, Voulé S, Deussing JM and Kimura M. Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery. Sleep 2015 Sep 1;38(9):1371-8

Falkai P, Rossner MJ, Schulze TG,Hasan A, Brzózka MM, Malchow B, Honer WG, Schmitt A. Kraepelin revisited: schizophrenia from degeneration to failed regeneration. Mol Psychiatry. 2015 Jun;20(6):671-6

Shi S, Wagner J, Mitteregger-Kretzschmar G, Ryazanov S, Leonov A, Griesinger C and Giese A. Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice. J Neuropathol Exp Neurol. 2015 Sep;74(9):924-33. 

Deeg AA, Reiner AM, Schmidt F, Schueder F, Ryazanov S, Ruf VC, Giller K, Becker S, Leonov A, Griesinger C, Giese A, Zinth W. Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates.  Biochim Biophys Acta. 2015 Sep;1850(9):1884-90.

Gogolla, N. The Insular Cortex. Current Biology, Vol 27/12, 19 June 2017, R580–R586

Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron 2014 Aug 20; 83, 894-905

Hasan A, Guse B, Cordes J, Wölwer W, Winterer G, Gaebel W, Langguth B, Landgrebe M, Eichhammer P, Frank E, Hajak G, Ohmann C, Verde PE, Rietschel M, Ahmed R, Honer WG, Malchow B, Karch S, Schneider-Axmann T, Falkai P, Wobrock T. Cognitive Effects of High-Frequency rTMS in Schizophrenia Patients With Predominant Negative Symptoms: Results From a Multicenter Randomized Sham-Controlled Trial. Schizophr Bull. 2015 Oct 3. pii: sbv142. 

Wobrock T, Guse B, Cordes J, Wölwer W, Winterer G, Gaebel W, Langguth B, Landgrebe M, Eichhammer P, Frank E, Hajak G, Ohmann C, Verde PE, Rietschel M, Ahmed R, Honer WG, Malchow B, Schneider-Axmann T, Falkai P, Hasan A. Left prefrontal high-frequency rTMS for the Treatment of Schizophrenia with Predominant Negative Symptoms – A Sham-controlled, Randomized Multicentre Trial. Biological Psychiatry 2015 Jun; 77(11):979-88

Strube W, Bunse T, Nitsche MA, Wobrock T, Aborowa R, Misewitsch K, Herrmann M, Falkai P, Hasan A. Smoking restores impaired LTD-like plasticity in schizophrenia: a transcranial direct current stimulation study. Neuropsychopharmacology. 2015 Mar;40(4):822-30.

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