I am interested in the molecular pathology of neurodegenerative diseases such as dementia. One of my goals is the collection of neurodegenerative cases into a brain bank. I am involved in the molecular classification of diseases and neuropathological consensus criteria of brain banking including ethical issues.
As part of the Ministry of Education and Research (BMBF)-funded “Integrated, systems-based approach for pathway analysis in psychiatric disease” (IntegraMent) project, we conduct epigenetic investigations of post-mortem brain regions of patients with psychiatric disorders such as schizophrenia. Furthermore, my group is working on protein aggregation and toxic oligomers in neurodegenerative disease using confocal single-particle fluorescence spectroscopy.At the Center of Neuropathology we also focus on research into Prion diseases (e.g. BSE) and prion-like mechanisms of neurodegeneration identified in post-mortem brains. We have developed sensitive amplification techniques for the detection of protein aggregates. Additonally, we are involved in drug-development for Parkinson's and Prion disease, e.g. the oligomer modulator Anle138b. Finally, we are working on the development of molecular biomarkers for neuropathological diagnosis.