Welcome

Panel Interviews of invited candidates by the IMPRS-TP faculty members. [more]

The Lead Discovery Center GmbH (LDC) transforms results from basic research into novel drug candidates. LDC collaborates with basic researchers to leverage excellent biomedical basic research. LDC's academic network represents thousands of scientists and a large pipeline of novel ideas for treating diseases with unmet medical need. LDC has established a flexible, but industry-type drug discovery infrastructure. LDC's current portfolio contains ~20 highly innovative and collaborative drug discovery projects. LDC tries to transform these innovative early-stage projects into attractive licensing opportunities. It has built up an excellent track record in partnering projects to industrial partners, like Bayer AG, Boehringer Ingelheim, Merck KGaA, Qurient etc. [more]

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High cardiovascular mortality is well documented in lean phenotypes exhibiting visceral fat accumulation. In contrast, corpulent phenotypes with predominantly subcutaneous fat accumulation display a surprisingly low mortality. The term ‘obesity paradox’ reflects the difficulty in understanding the biological mechanisms underlying these clinical observations. [more]

Metacognition can be defined as the monitoring and control of lower-level cognitive processes. There are at least two levels of metacognition. Implicit metacognition, an automatic, sub-personal process, can often display optimal levels of control. This is not the case for conscious, explicit metacognition. Many features of schizophrenia, such as thought insertion and lack of insight, reflect disorders of metacognition. However, experimental studies suggest that these disorders only emerge at the explicit level of metacognition. [more]

Mental illness accounts for 28% of disease burden among non-communicable diseases . Environmental factors account for up to 20% of the attributable risk for mental disorders. To advance precision medicine in psychiatry, we therefore need to take into account environmental and lifestyle factors, and characterise the biological and neuronal mechanisms that mediate their effect on behaviour. [more]