Adrenal corticosteroid hormones are potent modulators of the brain via mineralo- and glucocorticoid receptors, MR and GR. MR and GR function in large measure as transcription factors. Not only do they mediate different effects even within the same neurons, these effects may also differ substantially between different (neuronal) cell types. Aberrant MR/GR signalling may be causal to the development of a range of psychopathologies.
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