Welcome

Laura Voss (*1984) is a Munich­based collage artist. Her collages range from complex landscapes to surrealistic portraits of human­animal hybrid figures. [more]

with Markus Heinrichs, Jonathan Seckl, Helen Mayberg, René Hen [more]

For many brain diseases, particularly in psychiatry, we lack clinical tests for differential diagnosis and cannot predict optimal treatment for individual patients. This presentation outlines a translational neuromodeling framework which aims at establishing “computational assays” for inferring subject-specific mechanisms of brain disease from non-invasive measures of behaviour and neuronal activity. [more]

Chronic stress plays a crucial role in the development of psychiatric diseases, such as anxiety and depression. Dysfunction of the medial prefrontal cortex (mPFC) has been linked to the cognitive and emotional deficits induced by stress. However, little is known about the molecular and cellular determinants in mPFC leading to stress-associated mental disorders. Here we show that chronic restraint stress induces the selective loss of p11 (also known as annexin II light chain, S100A10), a multifunctional protein which binds to 5-HT receptors, in layer II/III neurons of the prelimbic cortex (PrL), as well as depression-like behaviors, both of which are reversed by selective serotonin reuptake inhibitors (SSRIs) and the tricyclic class of antidepressant (TCA) agents. [more]