Mitochondrial metabolism controls early lineage progression and ageing phenotypes in adult hippocampal neurogenesis
External Seminar
Directions
- Date: Dec 9, 2015
- Time: 05:00 PM - 06:00 PM (Local Time Germany)
- Speaker: Dr. Ruth Beckervordersandforth
- Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
- Location: LMU BioCenter Martinsried, Großhaderner Str. 2, 82152 Martinsried
- Room: Lecture Room B01.027
- Host: Graduate School Life Science Munich (LSM)
- Contact: lsm@biologie.uni-muenchen.de
Precise regulation of cellular metabolism is hypothesized to constitute a vital component of the developmental sequence underlying the life-long generation of hippocampal neurons from quiescent neural stem cells. The identity of stage-specific metabolic programs and their impact on neurogenesis, however, are largely unknown.
We show that activity of mitochondrial complexes functionally demarcates the transition from activated neural stem cells to intermediate neural progenitors. Intriguingly, perturbation of the function of mitochondrial complexes by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of ageing in hippocampal neurogenesis, whereas pharmacological enhancement of mitochondrial function ameliorates age-associated neurogenesis defects. These data link mitochondrial complex function to lineage progression of adult neural stem cells and identify mitochondrial function as a potential target to restore neurogenesis in the ageing hippocampus.