Transcriptional networks of resilience and susceptibility
Seminar
- Date: Mar 21, 2019
- Time: 01:00 PM - 02:00 PM (Local Time Germany)
- Speaker: Dr Rosemary C. Bagot
- Departments of Psychology & Psychiatry McGill University, Ludmer Centre Researcher, Montreal, Canada
- Location: Max Planck Institute of Psychiatry
- Room: Lecture Hall
- Host: Dr Juan Pablo Lopez
- Contact: jplopez@psych.mpg.de
Integrative network analysis of a large-scale RNA-sequencing data set from multiple brain regions in control, susceptible and resilient mice identified transcriptional networks that regulate susceptibility or resilience in distinct brain regions. In vivo manipulations of multiple key regulators confirmed the functional significance of these networks by assessing the effects of viral-mediated over-expression of identified network hub-genes in mice exposed to CSDS on depression associated behavioral assays, electrophysiological assays of synaptic function and transcriptional regulation of gene networks. These results demonstrate that states of resilience and susceptibility are driven by distinct circuit-level transcriptional networks and confirm the utility of a systems biology approach in identifying novel transcriptional mechanisms of stress susceptibility and resilience that may offer new targets to reverse susceptibility or induce resilience.