Manipulating stem cells to increase neuron numbers in the adult mammalian brain: from cells to behaviour.
Seminar
- Date: Oct 1, 2015
- Time: 02:00 PM - 03:00 PM (Local Time Germany)
- Speaker: Prof. Federico Calegari
- DFG-Research Center and Cluster of Excellence for Regenerative Therapies, TU‐Dresden
- Location: Max Planck Institute of Psychiatry
- Room: Kraepelin Seminarroom
- Host: Silvia Cappello
- Contact: silvia_cappello@psych.mpg.de
The goal of our laboratory is to control the expansion of neural stem cells (NSC) and the generation of neurons in the mammalian brain in order to understand the role of adult neurogenesis in brain function, behavior and therapy.
We found that a transient manipulation of the length of the G1 phase of the cell cycle of NSC can be used as a means to increase neurogenesis in development and adulthood (Lange et al., 2009; Artegiani et al., 2011). Ongoing experiments aim to address whether or not this acute increase in neurogenesis positively contributes to brain function, learning, memory or recovery upon injury.
In addition, we use a number of approaches to identify the mechanisms underlying the physiological proliferation vs differentiation of NSC, including regulation by long non-coding RNAs.