Host & Contact

PD Dr. Carsten Wotjak
PD Dr. Carsten Wotjak
Research Group Leader
Phone: +49 89 30622-652

Recommended Reading

[1] American Psychiatric Association: Diagnostic and statistical manual of mental disorders (5th ed.). ed. A.P. Publishing 2013, Arlington,VA.

[2] Jones CA, Watson DJ, Fone KC (2011). Animal models of schizophrenia. Br J Pharmacol. 164:1162-94.

[3] Kucerova J, Tabiova K, Drago F, Micale V. (2014).Therapeutic potential of cannabinoids in schizophrenia. Recent Pat CNS Drug Discov. 9:13-25


August 2018
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13259 1520514917

Targeting the endogenous cannabinoid system (ECS) in schizophrenia: preclinical and clinical evidence

  • Date: Mar 15, 2018
  • Time: 11:00 - 12:00
  • Speaker: Vincenzo Micale
  • Department of Biomedical and Biotechnological Sciences | University of Catania | Italy
  • Location: Max Planck Institute of Psychiatry
  • Room: Kraepelin Museum KRAE19
  • Host: Carsten Wotjak
  • Contact:
Schizophrenia (SCZ) is a debilitating psychiatric disease, characterized by three classes of symptoms: positive, negative and cognitive/attention deficit. Antipsychotics are generally effective to treat positive symptoms, but they have moderate effects on the others; thus there is a need to develop novel therapeutics [1].

The aetiopathology of SCZ is still partially understood and several hypotheses are mostly based on dopaminergic or glutamatergic dysfunction. However, it is widely assumed that SCZ should be a developmental disease that becomes evident in adulthood, with both genetic and environmental risk factors playing a role during embryogenesis [2]. Cannabis and endocannabinoids seem to play a pivotal role in the genesis of SCZ. Cannabis sativa is one of the most frequently abused substances among SCZ patients and adolescence use of Cannabis may pose a potential environmental risk to develop psychosis. Cannabis derivatives produce their CNS effect through activation of the endocannabinoid system (ECS), a recently discovered signaling system comprising specific receptors (the CB1 and CB2 receptors), their intrinsic lipid ligands (AEA and 2-AG) and the associated enzymatic machinery (transporters, biosynthetic and degradative enzymes). A variety of animal and human studies found a dysregulation of the ECS (both in term of cannabinoid receptors and endocannabinoid ligands) in psychosis. Modulation of this system by the main psychoactive component in cannabis, Δ9-tetrahydrocannabinol (THC), induces acute psychotic effects and cognitive impairment. However, the non-psychotropic, plant-derived cannabinoid agent cannabidiol (CBD) may have antipsychotic properties (Kucerova et al., 2014). Thus, due to the partial efficacy of actual antipsychotics, compounds which modulate this system may provide a novel therapeutic target for the treatment of schizophrenia.

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