Welcome to the IMPRS-TP

Welcome

Host: International Max Planck Research School for Translational Psychiatry (IMPRS-TP)

IMPRS-TP Interview Week

Recruitment
Projects available will be presented to invited candidates by the IMPRS-TP faculty members during the interview week. [more]
Projects available will be presented to invited candidates by the IMPRS-TP faculty members during the interview week. [more]

Precision Medicine and Global Mental Health.

Special Seminar
Precision medicine aims to reduce the burden of mental disorders by identifying disease markers based on neural processes that predict psychopathology and enable stratification for targeted interventions. [more]

Towards neural repair: turning scar forming glia into neurons

Munich Psychiatry Lecture Series | MPLS
We aim to understand neurogenesis when and how it works – during development and in the few niches of adult neurogenesis – in order to reinstall neurogenesis when needed after brain injury. [more]

Chromatin-directed alternative splicing in brain reward regions

Munich Psychiatry Lecture Series | MPLS
Regulation of gene expression via stably altered chromatin is a compelling area of study for highly heritable neuropsychiatric diseases, such as addiction (Walker, Cates, Heller, & Nestler, 2015). However, due to the promiscuous nature of chromatin-remodeling factors (Kennedy et al., 2013; Maze et al., 2011), previous studies have largely failed to distinguish between the mere presence and the functional relevance of drug-induced histone post-translational modifications (HPTMs). [more]

Central amygdala circuits that regulate appetite behavior

Munich Psychiatry Lecture Series | MPLS
The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummatory behaviors outside of these regions is poorly understood. The central nucleus of the amygdala (CeA) has been implicated in feeding and reward, but the neurons and circuit mechanisms that positively regulate these behaviors have remained unclear until recently. We have defined the neuronal mechanisms by which CeA neurons promote food consumption. [more]

Neural control of human defensive reactions to social threat

Munich Psychiatry Lecture Series | MPLS
The ability to control automatic emotional actions constitutes a critical component of emotion regulation during socially threatening situations. For instance, under acute social threat, goal directed decision-making depends largely on the capacity to override automatic defensive actions such as freezing reactions or fight-or-flight actions. Distinct parts of the frontal cortex are implicated in regulating these defensive reactions. [more]
We are welcoming 24 candidates from 13 countries, flying in from as far as South Africa, Guatemala and China. [more]

The environment, brain and behaviour: results from large scale neuroimaging cohorts

Seminar
Mental illness accounts for 28% of disease burden among non-communicable diseases . Environmental factors account for up to 20% of the attributable risk for mental disorders. To advance precision medicine in psychiatry, we therefore need to take into account environmental and lifestyle factors, and characterise the biological and neuronal mechanisms that mediate their effect on behaviour. [more]

Looking back to move forward: Bridging the gap: From large-scale aggregation to individual prediction

Munich Psychiatry Lecture Series | MPLS
Over the last two decades, neuroimaging has provided ample knowledge on the structure, function and connectivity of the human brain as well as the aberrations thereof in patients with neurological and psychiatric disorders. In this context, the long predominant paradigm has been to compare (mean) local volume or activity between groups, or to correlate these to behavioral phenotypes. Such approach, however, is intrinsically limited in terms of possible insight into inter-individual differences and application in clinical practice. Recently, the increasing availability of large cohort data and tools for multivariate statistical learning, allowing the prediction of individual cognitive or clinical phenotypes in new subjects, have started a revolution in imaging neuroscience. [more]

How do antidepressants work?

Munich Psychiatry Lecture Series | MPLS
Antidepressant drug action has typically been considered at the neurochemical, cellular and molecular level. However, it is unclear how these changes become translated into the psychological changes in symptoms seen during treatment in depression. [more]

Modelling brain development in health and disease using on-chip organoids

Munich Psychiatry Lecture Series | MPLS
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