CNS-dependent control of metabolism
Munich Psychiatry Lecture Series | MPLS
- New location!
- Date: Jun 27, 2017
- Time: 03:00 PM - 04:00 PM (Local Time Germany)
- Speaker: Jens C. Brüning
- Max Planck Institute for Metabolism Research, Cologne, Germany
- Location: Max Planck Institute of Psychiatry
- Room: Kraepelin Seminarroom
- Host: Elisabeth Binder
- Contact: binder@psych.mpg.de
Melanocortin neurons in the arcuate nucleus of the hypothalamus integrate different hormla signals from the periphery of the organism, which communicate fuel availibility of the organism, such as leptin, insulin and glucose. In turn, these neurons coordinate behavioral and autonomic responses to adapt food intake and energy expenditure. From an evolutionary point of view it is reasonable that these neurocircuits not only adapt food intake and energy expenditure according to fuel availability, but that they also coordinate the fluxes of fuels across different organs.
The presentation will focus on the identification and functional characterization of melanocortin-dependent neurocircuits, which also control peripheral insulin sensivity and glucose homeostasis.