L2 Methods in neurogenetics - from genes to behavior and physiology
Chen, Wotjak, Deussing, Attardo, Heil, Baier, Pantoja, Gogolla, Wehr, Cappello, DiGiaimo, Binder, Schilbach, Bolis, Ing, Schumann
The ability of organisms to translate their genetic code into behavioral and physiological functions is intriguing. The conceptually multi-step gap between the genotype and phenotype is undoubtedly one of the foremost challenges we are facing today in the field of neuroscience. This basic course will present different genetic approaches and relevant studies in the scientific domain of behavioral and physiological neurogenetics. Neurogenetics employs state-of-the-art molecular and genetic techniques together with behavioral, cognitive and physiological methodologies, in order to address questions concerning the influence of biological and environmental factors on individuals with different disorders and psychopathologies, or concerning normal variations between individuals. The commonly used model organisms (C. elegans, Drosophila fruit fly, zebrafish and mouse) in neurogenetics research will be presented as well as methods using pluripotent stem cells. A variety of genetic techniques, viral approaches, optogenetic methodologies, epigenetics and human behavioral genetics will be discussed.
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